I am unable to update latest version. I get the message of "Windows cannot access the specified device, path, or file. ..."

you are getting it from the tixati website right?

https://download1.tixati.com/download/tixati-2.84-1.win64-install.exe

windows defender could be interfering with your installing of tixati.
try going to defender settings and allowing tixati.

Windows is interfering with the installation of a lot of torrent clients.