can tixati works along this softwares?

Yes you can, but support for PeerGuardian has been discontinued and replaced by PeerBlock.

perhaps, but don't get any false sense of security. what do you think peerguardian protects you from?

I do not believe in blocklists, but if you want to use one - Tixati has a built in IP filter feature that you can have automatically get the Level 1 blocklist (the most used blocklist) from I Blocklist.